My research interest is to investigate the role of membrane transport proteins in determining drugs and endogenous molecules disposition and their role in neurological diseases, mainly Alzheimer’s disease. Investigating and understanding transport proteins is fundamental to facilitate therapeutic development and delivery. Transport proteins are widely acknowledged as important determinants governing absorption, clearance, and, in many cases, extent of entry into target organs. There is also a greater appreciation that altered transporter function, whether due to aging, genetic polymorphisms, drug interactions, or environmental factors such as dietary constituents, can result in unexpected adverse effects. Such effects are in part due to the interplay between various uptake and efflux transport proteins with overlapping functional capabilities that can appear as marked inter-individual variability in drugdisposition in vivo, and possible susceptibility to diseases.
|Amal Khalil Kaddoumi, Ph.D.
Associate Professor of Pharmaceutics
Department of Basic Pharmaceutical Sciences
School of Pharmacy
University of Louisiana at Monroe
Monroe, LA 71209-0497